Blood Spotlight The new genetics of chronic neutrophilic leukemia and atypical CML: implications for diagnosis and treatment
نویسندگان
چکیده
In clinical practice, neutrophilia most commonly relates to leukemoid reactions due to chronic infections, inflammatory diseases, or various types of malignancies. Cytokine-driven neutrophilia accompanying plasma cell neoplasms is a well-described association. Chronic neutrophilic leukemia (CNL) is a rare myeloproliferative neoplasm, with only ;200 patients reported to date, mostly culled from case reports and small case series. Atypical chronic myeloid leukemia (aCML) is an uncommon myelodysplastic/myeloproliferative (MDS/ MPN) neoplasm, with a relative incidence estimated at 1 to 2 cases for every 100 patients withBCR-ABL1-positive chronic myeloid leukemia (CML).
منابع مشابه
The new genetics of chronic neutrophilic leukemia and atypical CML: implications for diagnosis and treatment.
Although activation of tyrosine kinase pathways is a shared theme among myeloproliferative neoplasms, the pathogenetic basis of chronic neutrophilic leukemia (CNL) has remained elusive. Recently, we identified high-frequency oncogenic mutations in the granulocyte-colony stimulating factor receptor (CSF3R) in CNL and in some patients with atypical chronic myeloid leukemia. Inhibition of Janus ki...
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